- Lamar Jackson is the first player in FBS history to have two seasons with 1,000 rushing yards and 3,000 passing yards. Previously, seven players achieved it once in their careers.
- Jackson surpassed 100-yards rushing in the first quarter, extending his school record with his 20th career 100-yard rushing game. It puts him in a tie for sixth-place with NC State's Joe McIntosh (1981-84) in ACC history.
- Jackson's 147 yards give him seven 100-yard games – tying him with Louisville's Bilal Powell (2010), Frank Moreau (1999) and Walter Peacock (1973).
- Jackson has moved into eighth place on the NCAA's career list for rushing yards by a quarterback with 3,707 yards.
- With his seventh 100-yard rushing game this year, Jackson is the only player in Louisville history to have seven or more 100-yard rushing games in two different seasons. He had a school-record eight in 2016.
- Jackson's 17th rushing touchdown this year moves him into a tie for sixth with Frank Moreau (1999) for most rushing TDs in a season at Louisville.
- Jackson's 63rd career passing touchdowns moved him into a tie for 13th place on the ACC's career passing touchdowns list.
- Jackson achieved the fourth season in Louisville history with 4,000 yards of total offense by an individual (Chris Redman, 1998; Teddy Bridgewater, 2013; Lamar Jackson, 2016).